In 2009, the RE-COVER study compared dabigatran to warfarin based on how well the drugs treated acute venous thromboembolism (VTE). In the RE-LY trial, dabigatran significantly reduced the risk of stroke in patients with nonvalvular Afib compared with warfarin. What are the benefits?ĭabigatran is an effective and safe alternative to warfarin.
In the event of major or life-threatening bleeding, dabigatran can be reversed with an antidote called idarucizumab (Praxbind ®). Dabigatran may also cause patients to bruise more easily. Patients on dabigatran should always talk to a healthcare provider before having any type of surgery, medical procedure, or dental procedure. Patients on dabigatran may have a higher risk of bleeding, especially if they’re older than age 75, have kidney problems, or have had recent stomach or intestinal bleeding or stomach ulcers. “Dabigatran inhibits what the thrombin is doing, stops the fibrinogen from forming fibrin, and prevents the blood from clotting.” What are the risks?Īs with any medication, dabigatran has risks.
Azhar Ahmad, the executive director of clinical development and medical affairs at Boehringer Ingelheim. Another entity called thrombin needs to be activated for the conversion to take place.” explained Dr. Fibrin forms when it’s converted from its precursor, fibrinogen. “When a blood clot forms, one of the main ingredients for it is fibrin. Dabigatran binds itself to thrombin molecules, preventing them from initiating a blood clot. This means that it works to block a clotting agent known as thrombin. How does it work?ĭabigatran is a direct thrombin inhibitor. It reduces the risk of blood clot-related issues, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke from atrial fibrillation (Afib not caused by a heart valve problem). What is it?ĭabigatran, also known as Pradaxa ® is a pill taken twice a day every 12 hours. These anticoagulants include apixaban, dabigatran, edoxaban, rivaroxaban, and betrixaban. DOACs are considered more effective and safer than warfarin, especially with regard to serious bleeding episodes.
For the past several decades, warfarin has been the go-to anticoagulant drug, but newer treatments have emerged in the form of direct oral anticoagulants (DOACs).
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